Medication Misadventures in Older Adults: Literature from 2013
Identifieur interne : 004842 ( Main/Exploration ); précédent : 004841; suivant : 004843Medication Misadventures in Older Adults: Literature from 2013
Auteurs : Joseph T. Hanlon [États-Unis] ; Todd P. Semla [États-Unis] ; Kenneth E. Schmader [États-Unis]Source :
- Journal of the American Geriatrics Society [ 0002-8614 ] ; 2014-10.
Descripteurs français
- KwdFr :
- Antagonistes cholinergiques (effets indésirables), Bilan comparatif des médicaments, Essais cliniques comme sujet, Humains, Inhibiteurs du symport chlorure sodium (usage thérapeutique), Pharmaciens, Prescription inappropriée (), Rôle professionnel, Sujet âgé, Syndrome anticholinergique (), Troubles de la cognition ().
- MESH :
- effets indésirables : Antagonistes cholinergiques.
- usage thérapeutique : Inhibiteurs du symport chlorure sodium.
- Bilan comparatif des médicaments, Essais cliniques comme sujet, Humains, Pharmaciens, Prescription inappropriée, Rôle professionnel, Sujet âgé, Syndrome anticholinergique, Troubles de la cognition.
- Pascal (Inist)
- Wicri :
- topic : Gérontologie, Littérature, Médicament, Personne âgée.
English descriptors
- KwdEn :
- Age, Aged, Anticholinergic Syndrome (prevention & control), Chemotherapy, Cholinergic Antagonists (adverse effects), Clinical Trials as Topic, Cognition Disorders (chemically induced), Cognition Disorders (prevention & control), Complication, Drug, Elderly, Epidemiology, Error, Geriatrics, Gerontology, Humans, Iatrogenic, Inappropriate Prescribing (prevention & control), Literature, Medication Reconciliation, Pharmacists, Pharmacotherapy, Pharmacovigilance, Professional Role, Secondary effect, Sodium Chloride Symporter Inhibitors (therapeutic use), Toxicity, Treatment efficiency.
- MESH :
- chemical , adverse effects : Cholinergic Antagonists.
- chemically induced : Cognition Disorders.
- prevention & control : Anticholinergic Syndrome, Cognition Disorders, Inappropriate Prescribing.
- chemical , therapeutic use : Sodium Chloride Symporter Inhibitors.
- Aged, Clinical Trials as Topic, Humans, Medication Reconciliation, Pharmacists, Professional Role.
Abstract
The objective of this paper is to review articles published in 2013 examining drug‐related problems in the elderly and comment on their potential impact on clinical practice. To identify articles, we did a systematic search of the English‐language literature restricted to those aged 65 + from January 2013 to December 2013 using Medline and Google Scholar and a combination of the following search terms: drug‐related problems, medication‐related problems, medication errors, suboptimal prescribing, inappropriate prescribing, underutilization, polypharmacy, medication monitoring, medication dispensing, medication administration, medication adherence, adverse drug events, and adverse drug withdrawal events. A manual search of major general medicine and clinical pharmacology journals was also conducted to identify additional articles. A total of 51 articles were identified of which 20 were chosen to highlight. Three were annotated and critiqued and the additional 17 articles were summarized in an appendix. One article reported the results of a randomized controlled trial that showed that a pharmacist intervention successfully reduced suboptimal prescribing in older hospital patients. Another paper from this group previously reported data from the same study showing that the intervention also reduced medication related readmissions to the hospital. An observational study compared the use of two thiazide diuretics in older outpatients. They found that chlorthalidone was more likely to cause hypokalemia than hydrochlorothiazide. Finally, in a randomized controlled trial a pharmacist intervention resulted in the reduction of anticholinergic burden but did result in an improvement in cognition. These studies highlight that medication errors and adverse drug events continue to be important issues for health care professionals caring for older adults.
Url:
DOI: 10.1111/jgs.13026
Affiliations:
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Le document en format XML
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Hanlon, Department of Medicine (Geriatrics), University of Pittsburgh, Kaufman Medical Building, Suite 514, 3471 5th Ave, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Semla, Todd P" sort="Semla, Todd P" uniqKey="Semla T" first="Todd P." last="Semla">Todd P. 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Schmader</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Division of Geriatrics, Department of Medicine, School of Medicine, Duke University Medical Center, Durham</wicri:cityArea></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of the American Geriatrics Society</title><title level="j" type="alt">JOURNAL OF THE AMERICAN GERIATRICS SOCIETY</title><idno type="ISSN">0002-8614</idno><idno type="eISSN">1532-5415</idno><imprint><biblScope unit="vol">62</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1950">1950</biblScope><biblScope unit="page" to="1953">1953</biblScope><biblScope unit="page-count">4</biblScope><date type="published" when="2014-10">2014-10</date></imprint><idno type="ISSN">0002-8614</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-8614</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age</term><term>Aged</term><term>Anticholinergic Syndrome (prevention & control)</term><term>Chemotherapy</term><term>Cholinergic Antagonists (adverse effects)</term><term>Clinical Trials as Topic</term><term>Cognition Disorders (chemically induced)</term><term>Cognition Disorders (prevention & control)</term><term>Complication</term><term>Drug</term><term>Elderly</term><term>Epidemiology</term><term>Error</term><term>Geriatrics</term><term>Gerontology</term><term>Humans</term><term>Iatrogenic</term><term>Inappropriate Prescribing (prevention & control)</term><term>Literature</term><term>Medication Reconciliation</term><term>Pharmacists</term><term>Pharmacotherapy</term><term>Pharmacovigilance</term><term>Professional Role</term><term>Secondary effect</term><term>Sodium Chloride Symporter Inhibitors (therapeutic use)</term><term>Toxicity</term><term>Treatment efficiency</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antagonistes cholinergiques (effets indésirables)</term><term>Bilan comparatif des médicaments</term><term>Essais cliniques comme sujet</term><term>Humains</term><term>Inhibiteurs du symport chlorure sodium (usage thérapeutique)</term><term>Pharmaciens</term><term>Prescription inappropriée ()</term><term>Rôle professionnel</term><term>Sujet âgé</term><term>Syndrome anticholinergique ()</term><term>Troubles de la cognition ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Cholinergic Antagonists</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antagonistes cholinergiques</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Anticholinergic Syndrome</term><term>Cognition Disorders</term><term>Inappropriate Prescribing</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Sodium Chloride Symporter Inhibitors</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Inhibiteurs du symport chlorure sodium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Clinical Trials as Topic</term><term>Humans</term><term>Medication Reconciliation</term><term>Pharmacists</term><term>Professional Role</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Bilan comparatif des médicaments</term><term>Essais cliniques comme sujet</term><term>Humains</term><term>Pharmaciens</term><term>Prescription inappropriée</term><term>Rôle professionnel</term><term>Sujet âgé</term><term>Syndrome anticholinergique</term><term>Troubles de la cognition</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Age</term><term>Chimiothérapie</term><term>Complication</term><term>Effet secondaire</term><term>Efficacité traitement</term><term>Epidémiologie</term><term>Erreur</term><term>Gériatrie</term><term>Gérontologie</term><term>Iatrogène</term><term>Littérature</term><term>Médicament</term><term>Personne âgée</term><term>Pharmacothérapie</term><term>Pharmacovigilance</term><term>Toxicité</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Gérontologie</term><term>Littérature</term><term>Médicament</term><term>Personne âgée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">The objective of this paper is to review articles published in 2013 examining drug‐related problems in the elderly and comment on their potential impact on clinical practice. To identify articles, we did a systematic search of the English‐language literature restricted to those aged 65 + from January 2013 to December 2013 using Medline and Google Scholar and a combination of the following search terms: drug‐related problems, medication‐related problems, medication errors, suboptimal prescribing, inappropriate prescribing, underutilization, polypharmacy, medication monitoring, medication dispensing, medication administration, medication adherence, adverse drug events, and adverse drug withdrawal events. A manual search of major general medicine and clinical pharmacology journals was also conducted to identify additional articles. A total of 51 articles were identified of which 20 were chosen to highlight. Three were annotated and critiqued and the additional 17 articles were summarized in an appendix. One article reported the results of a randomized controlled trial that showed that a pharmacist intervention successfully reduced suboptimal prescribing in older hospital patients. Another paper from this group previously reported data from the same study showing that the intervention also reduced medication related readmissions to the hospital. An observational study compared the use of two thiazide diuretics in older outpatients. They found that chlorthalidone was more likely to cause hypokalemia than hydrochlorothiazide. Finally, in a randomized controlled trial a pharmacist intervention resulted in the reduction of anticholinergic burden but did result in an improvement in cognition. These studies highlight that medication errors and adverse drug events continue to be important issues for health care professionals caring for older adults.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Illinois</li><li>Pennsylvanie</li></region><settlement><li>Chicago</li><li>Pittsburgh</li></settlement></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name></region><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name><name sortKey="Schmader, Kenneth E" sort="Schmader, Kenneth E" uniqKey="Schmader K" first="Kenneth E." last="Schmader">Kenneth E. Schmader</name><name sortKey="Semla, Todd P" sort="Semla, Todd P" uniqKey="Semla T" first="Todd P." last="Semla">Todd P. Semla</name><name sortKey="Semla, Todd P" sort="Semla, Todd P" uniqKey="Semla T" first="Todd P." last="Semla">Todd P. Semla</name><name sortKey="Semla, Todd P" sort="Semla, Todd P" uniqKey="Semla T" first="Todd P." last="Semla">Todd P. Semla</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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